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Lymphocyte subpopulations in myocardial infarction: a comparison between peripheral and intracoronary blood.
- Source :
-
SpringerPlus [Springerplus] 2015 Dec 01; Vol. 4, pp. 744. Date of Electronic Publication: 2015 Dec 01 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- The frequency and profile of lymphocyte subsets within the culprit coronary artery were investigated in 33 patients with myocardial infarction and compared to their systemic circulating counterparts. T cell subsets including CD4(+)CD28null, activated and regulatory T-cells, TH1/TH2/TH17 phenotypes, NK and B-cells were studied in intracoronary (IC) and arterial peripheral blood (PB) samples. CD4(+)CD28null T-lymphocytes were significantly increased in IC compared to PB (3.7 vs. 2.9 %, p < 0.0001). Moreover, patients with more than 6 h of evolution of STEMI exhibited higher levels of CD4(+)CD28null T-cells suggesting that this subset may be associated with more intense myocardial damage. The rare NK subpopulation CD3(-)CD16(+)CD56(-) was also increased in IC samples (5.6 vs. 3.9 %, p = 0.006). CD4(+)CD28null T-cells and CD3(-)CD16(+)CD56(-) NK subpopulations were also associated with higher CK levels. Additionally, IFN-γ and IL10 were significantly higher in IC CD4(+) lymphocytes. Particular immune cell populations with a pro-inflammatory profile at the site of onset were increased relative to their circulating counterparts suggesting a pathophysiological role of these cells in plaque instability, thrombi and myocardial damage.
Details
- Language :
- English
- ISSN :
- 2193-1801
- Volume :
- 4
- Database :
- MEDLINE
- Journal :
- SpringerPlus
- Publication Type :
- Academic Journal
- Accession number :
- 26693103
- Full Text :
- https://doi.org/10.1186/s40064-015-1532-3