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Involvement of the infralimbic cortex and CA1 hippocampal area in reconsolidation of a contextual fear memory through CB1 receptors: Effects of CP55,940.
- Source :
-
Neurobiology of learning and memory [Neurobiol Learn Mem] 2016 Jan; Vol. 127, pp. 42-7. Date of Electronic Publication: 2015 Dec 10. - Publication Year :
- 2016
-
Abstract
- The endocannabinoid system (ECS) has a pivotal role in different cognitive functions such as learning and memory. Recent evidence confirm the involvement of the hippocampal CB1 receptors in the modulation of both memory extinction and reconsolidation processes in different brain areas, but few studies focused on the infralimbic cortex, another important cognitive area. Here, we infused the cannabinoid agonist CP55,940 either into the infralimbic cortex (IL) or the CA1 area of the dorsal hippocampus (HPC) of adult male Wistar rats immediately after a short (3min) reactivation session, known to labilize a previously consolidated memory trace in order to allow its reconsolidation with some modification. In both structures, the treatment was able to disrupt reconsolidation in a relatively long lasting way, reducing the freezing response. To our notice, this is the first demonstration of ECS involvement in reconsolidation in the Infralimbic Cortex. Despite poorly discriminative between CB1 and CB2 receptors, CP55,940 is a potent agent, and these results suggest that a similar CB1-dependent circuitry is at work both in HPC and in the IL during memory reconsolidation.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
CA1 Region, Hippocampal drug effects
Fear drug effects
Male
Memory Consolidation drug effects
Prefrontal Cortex drug effects
Rats
Rats, Wistar
Receptor, Cannabinoid, CB1 agonists
CA1 Region, Hippocampal physiology
Cyclohexanols administration & dosage
Fear physiology
Memory Consolidation physiology
Prefrontal Cortex physiology
Receptor, Cannabinoid, CB1 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9564
- Volume :
- 127
- Database :
- MEDLINE
- Journal :
- Neurobiology of learning and memory
- Publication Type :
- Academic Journal
- Accession number :
- 26691779
- Full Text :
- https://doi.org/10.1016/j.nlm.2015.11.016