Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.

Authors :: Flack T
Constantin T
Penasse S
Dejeu J
Gennaro B
Jourdan M
Laguerre A
Pirrotta M
Monchaud D
Spinelli N
Defrancq E
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2016 Jan 26; Vol. 22 (5), pp. 1760-7. Date of Electronic Publication: 2015 Dec 21.
Publication Year :: 2016
Abstract: A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)