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Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(I) complexes.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2016 Jan 28; Vol. 45 (4), pp. 1546-53. Date of Electronic Publication: 2015 Dec 21. - Publication Year :
- 2016
-
Abstract
- Alkynyl(triphenylphosphine)gold(i) complexes carrying variously substituted propargylic amines have been synthesized and fully characterized in solution and solid state. High levels of toxicity (i.e. micromolar range) were recognized for a series of cancer cell lines with particular emphasis on HT29, IGROV1, HL60 and I407. In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7-7.9 μM).
- Subjects :
- Alkynes chemistry
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Cell Cycle drug effects
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Gold chemistry
Humans
Molecular Structure
Organogold Compounds chemical synthesis
Organogold Compounds chemistry
Structure-Activity Relationship
Tumor Cells, Cultured
Antineoplastic Agents pharmacology
Organogold Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9234
- Volume :
- 45
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 26687209
- Full Text :
- https://doi.org/10.1039/c5dt02905h