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High predicted strain coverage by the multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland.
- Source :
-
Vaccine [Vaccine] 2016 Jan 20; Vol. 34 (4), pp. 510-515. Date of Electronic Publication: 2015 Dec 11. - Publication Year :
- 2016
-
Abstract
- Neisseria meningitidis of serogroup B (MenB) is currently responsible for more than 70% of cases of invasive meningococcal disease (IMD) in Poland and Europe as a whole. The aim of this study was to estimate strain coverage of a multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland; the meningococcal antigen typing system (MATS) was used to test a panel of 196 invasive MenB strains isolated in Poland in 2010 and 2011. The strains were also characterized by MLST and sequencing of porA, factor H-binding protein (fHbp), Neisserial heparin-binding antigen (nhba) and Neisserial adhesin A (nadA) genes. MATS and molecular data were analyzed independently and in combination. The MATS results predicted that 83.7% (95% CI: 78.6-91.0%) of isolates would be covered by the 4CMenB vaccine; 59.2% by one vaccine antigen, 19.9% by two and 4.6% by three antigens. Coverage by each antigen was as follows: fHbp 73.0% (95% CI: 68.9-77.5%), NHBA 28.6% (95% CI: 13.3-47.4%), NadA 1.0% (95% CI: 1.0-2.0%) and PorA 10.2%. Molecular analysis revealed that the most frequent clonal complexes (ccs) were cc32 (33.2%), cc18 (17.9%) and cc41/44 (15.8%) with estimated coverage of 98.5%, 88.6% and 93.5%, respectively. Consistent with findings for other European countries, our study predicts high coverage by the 4CMenB vaccine in Poland.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adhesins, Bacterial genetics
Adolescent
Adult
Antigens, Bacterial genetics
Antigens, Bacterial immunology
Bacterial Proteins genetics
Bacterial Typing Techniques
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Humans
Infant
Infant, Newborn
Meningococcal Infections prevention & control
Multilocus Sequence Typing
Poland
Porins genetics
Serogroup
Young Adult
Meningococcal Vaccines immunology
Neisseria meningitidis, Serogroup B classification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 26686998
- Full Text :
- https://doi.org/10.1016/j.vaccine.2015.11.070