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Highly biocompatible collagen-Delonix regia seed polysaccharide hybrid scaffolds for antimicrobial wound dressing.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2016 Feb 10; Vol. 137, pp. 584-593. Date of Electronic Publication: 2015 Nov 10. - Publication Year :
- 2016
-
Abstract
- Biomaterials based entirely on biological resources are ideal for tissue engineering applications. Here we report the preparation of hybrid collagen scaffolds comprising gulmohar seed polysaccharide (GSP) and cinnamon bark extract as cross-linking agent. (1)H NMR spectrum of GSP confirms the presence of galactose and mannose in the ratio of 1:1.54, which was further corroborated using FT-IR. The hybrid scaffolds show better enzyme and thermal stability in contrast to pure collagen scaffold probably due to weak interactions from GSP and covalent interaction through cinnamaldehyde. Gas permeability and scanning electron microscopic analysis show that the porosity of the hybrid scaffolds is slightly reduced with the increase in the concentration of GSP. The infrared and circular dichroic spectral studies show that the secondary structure of the collagen did not change after the interaction with GSP and cinnamaldehyde. The hybrid scaffolds stabilized with cinnamaldehyde show good antimicrobial activity against the common multi-drug resistant wound pathogens. These results suggest that the prepared hybrid scaffolds have great potential for antimicrobial wound dressing applications.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Anti-Infective Agents pharmacology
Bacillus drug effects
Biocompatible Materials chemistry
Circular Dichroism
Collagen classification
Cross-Linking Reagents chemistry
Escherichia coli drug effects
Microscopy, Electron, Scanning
Oils, Volatile chemistry
Plant Extracts chemistry
Porosity
Tissue Engineering
Anti-Infective Agents chemistry
Collagen chemistry
Fabaceae chemistry
Polysaccharides chemistry
Seeds chemistry
Tissue Scaffolds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 137
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 26686167
- Full Text :
- https://doi.org/10.1016/j.carbpol.2015.11.015