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T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.
- Source :
-
Pain [Pain] 2016 Jan; Vol. 157 (1), pp. 255-263. - Publication Year :
- 2016
-
Abstract
- Oscillations are fundamental to communication between neuronal ensembles. We previously reported that pain in awake rats enhances synchrony in primary somatosensory cortex (S1) and attenuates coherence between S1 and ventral posterolateral (VPL) thalamus. Here, we asked whether similar changes occur in anesthetized rats and whether pain modulates phase-amplitude coupling between VPL and S1. We also hypothesized that the suppression of burst firing in VPL using Z944, a novel T-type calcium channel blocker, restores S1 synchrony and thalamocortical connectivity. Local field potentials were recorded from S1 and VPL in anesthetized rats 7 days after sciatic chronic constriction injury (CCI). In rats with CCI, low-frequency (4-12 Hz) synchrony in S1 was enhanced, whereas VPL-S1 coherence and theta-gamma phase-amplitude coupling were attenuated. Moreover, Granger causality showed decreased informational flow from VPL to S1. Systemic or intrathalamic delivery of Z944 to rats with CCI normalized these changes. Systemic Z944 also reversed thermal hyperalgesia and conditioned place preference. These data suggest that pain-induced cortical synchrony and thalamocortical disconnectivity are directly related to burst firing in VPL.
- Subjects :
- Action Potentials drug effects
Action Potentials physiology
Animals
Calcium Channels, T-Type
Cerebral Cortex physiopathology
Disease Models, Animal
Male
Neural Pathways drug effects
Neural Pathways physiopathology
Piperidines
Rats
Rats, Sprague-Dawley
Thalamus physiopathology
Acetamides pharmacology
Benzamides pharmacology
Calcium Channel Blockers pharmacology
Cerebral Cortex drug effects
Neuralgia physiopathology
Thalamus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6623
- Volume :
- 157
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pain
- Publication Type :
- Academic Journal
- Accession number :
- 26683108
- Full Text :
- https://doi.org/10.1097/j.pain.0000000000000362