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Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016; Vol. 50 (1), pp. 149-59. - Publication Year :
- 2016
-
Abstract
- Our goal in this study was to determine whether or not anserine/carnosine supplementation (ACS) is capable of preserving cognitive function of elderly people. In a double-blind randomized controlled trial, volunteers were randomly assigned to an ACS or placebo group at a 1:1 ratio. The ACS group took 1.0 g of an anserine/carnosine (3:1) formula daily for 3 months. Participants were evaluated by psychological tests before and after the 3-month supplementation period. Thirty-nine healthy elderly volunteers (60-78 years old) completed the follow-up tests. Among the tests, delayed recall verbal memory assessed by the Wechsler Memory Scale-Logical Memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0128). Blood analysis revealed a decreased secretion of inflammatory cytokines, including CCL-2 and IL-8, in the ACS group. MRI analysis using arterial spin labeling showed a suppression in the age-related decline in brain blood flow in the posterior cingulate cortex area in the ACS group, compared to the placebo group (p = 0.0248). In another randomized controlled trial, delayed recall verbal memory showed significant preservation in the ACS group, compared to the placebo group (p = 0.0202). These results collectively suggest that ACS may preserve verbal episodic memory and brain perfusion in elderly people, although further study is needed.
- Subjects :
- Adult
Aged
Brain anatomy & histology
Brain drug effects
Cytokines blood
Cytokines genetics
Dietary Supplements
Double-Blind Method
Female
Gene Expression Regulation drug effects
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Neuropsychological Tests
Oligonucleotide Array Sequence Analysis
Aging
Anserine pharmacology
Carnosine pharmacology
Memory, Episodic
Verbal Learning drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 26682691
- Full Text :
- https://doi.org/10.3233/JAD-150767