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Structure Elucidation, Antimicrobial and Cytotoxic Activities of a Halimane Isolated from Vellozia kolbekii Alves (Velloziaceae).
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2015 Dec; Vol. 12 (12), pp. 1891-901. - Publication Year :
- 2015
-
Abstract
- A new halimane diterpene was isolated from Vellozia kolbekii Alves (Velloziaceae) and identified as (5R,8R,9S,13R)-halim-1,10-ene-15,16-diol (1). It showed cytotoxicity against three human cancer cell lines, SF-295 (glioblastoma), MDA-MB-435 (melanoma), and HCT-8 (colon adenocarcinoma). In the mechanism of cytotoxic action, halimane 1 interferes in two major phases of the cell cycle: in S phase, in which DNA synthesis occurs and where it is very sensitive to damage, and G2M phase which is the phase of preparation for mitosis and mitosis itself, showing apoptosis-inducing properties. Antimicrobial activity towards Gram-positive and Gram-negative bacteria was studied and, against Bacillus cereus, B. subtilis, Escherichia coli, and Pseudomonas aeruginosa, a MIC value of 0.025 μM was observed for halimane 1, which is more active than the positive control chloramphenicol.<br /> (Copyright © 2015 Verlag Helvetica Chimica Acta AG, Zürich.)
- Subjects :
- Cell Cycle drug effects
Cell Line, Tumor
Circular Dichroism
Humans
Inhibitory Concentration 50
Plant Extracts chemistry
Plant Extracts isolation & purification
Anti-Infective Agents chemistry
Anti-Infective Agents pharmacology
Bacteria drug effects
Cell Survival drug effects
Cytotoxins chemistry
Cytotoxins pharmacology
Diterpenes chemistry
Magnoliopsida chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 12
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 26663842
- Full Text :
- https://doi.org/10.1002/cbdv.201500071