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Local cryosurgery and imiquimod: A successful combination for the treatment of locoregional cutaneous metastasis of melanoma: A case series.

Local cryosurgery and imiquimod: A successful combination for the treatment of locoregional cutaneous metastasis of melanoma: A case series.

Authors :
Rivas-Tolosa N
Ortiz-Brugués A
Toledo-Pastrana T
Baradad M
Traves V
Soriano V
Sanmartín V
Requena C
Martí R
Nagore E
Source :
The Journal of dermatology [J Dermatol] 2016 May; Vol. 43 (5), pp. 553-6. Date of Electronic Publication: 2015 Dec 12.
Publication Year :
2016

Abstract

Locoregional cutaneous metastases of melanoma (LCMM) represent a therapeutic challenge. Many treatment options are available with varying results. The combination of cryotherapy and imiquimod, two treatments with a possible synergistic effect, has not yet been described for treating this disease. In this paper, we aimed to show the response of LCMM to cryotherapy combined with topical imiquimod 5%. A retrospective review of 20 patients diagnosed with LCMM and treated with cryotherapy combined with topical imiquimod 5% between November 2000 and May 2014 at three institutions was performed. The locoregional cutaneous response was evaluated. After a mean of five sessions, 13 patients (65%) responded to treatment, eight (40%) of these completely and five (25%) partially. Systemic disease progressed in 16 (80%) patients. Cryotherapy followed by topical imiquimod 5% is simple to apply, has minimal adverse effects and provides response rates similar to other, more complex treatment options.<br /> (© 2015 Japanese Dermatological Association.)

Details

Language :
English
ISSN :
1346-8138
Volume :
43
Issue :
5
Database :
MEDLINE
Journal :
The Journal of dermatology
Publication Type :
Academic Journal
Accession number :
26660713
Full Text :
https://doi.org/10.1111/1346-8138.13197