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Local cryosurgery and imiquimod: A successful combination for the treatment of locoregional cutaneous metastasis of melanoma: A case series.
Local cryosurgery and imiquimod: A successful combination for the treatment of locoregional cutaneous metastasis of melanoma: A case series.
- Source :
-
The Journal of dermatology [J Dermatol] 2016 May; Vol. 43 (5), pp. 553-6. Date of Electronic Publication: 2015 Dec 12. - Publication Year :
- 2016
-
Abstract
- Locoregional cutaneous metastases of melanoma (LCMM) represent a therapeutic challenge. Many treatment options are available with varying results. The combination of cryotherapy and imiquimod, two treatments with a possible synergistic effect, has not yet been described for treating this disease. In this paper, we aimed to show the response of LCMM to cryotherapy combined with topical imiquimod 5%. A retrospective review of 20 patients diagnosed with LCMM and treated with cryotherapy combined with topical imiquimod 5% between November 2000 and May 2014 at three institutions was performed. The locoregional cutaneous response was evaluated. After a mean of five sessions, 13 patients (65%) responded to treatment, eight (40%) of these completely and five (25%) partially. Systemic disease progressed in 16 (80%) patients. Cryotherapy followed by topical imiquimod 5% is simple to apply, has minimal adverse effects and provides response rates similar to other, more complex treatment options.<br /> (© 2015 Japanese Dermatological Association.)
- Subjects :
- Administration, Cutaneous
Aged
Aged, 80 and over
Aminoquinolines administration & dosage
Antineoplastic Agents administration & dosage
Combined Modality Therapy
Female
Humans
Imiquimod
Male
Melanoma drug therapy
Melanoma pathology
Melanoma surgery
Middle Aged
Neoplasm Metastasis
Retrospective Studies
Skin Neoplasms drug therapy
Skin Neoplasms pathology
Skin Neoplasms surgery
Aminoquinolines therapeutic use
Antineoplastic Agents therapeutic use
Cryosurgery
Melanoma therapy
Skin Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1346-8138
- Volume :
- 43
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 26660713
- Full Text :
- https://doi.org/10.1111/1346-8138.13197