Influence of polymer molecular weight on the in vitro cytotoxicity of poly (N-isopropylacrylamide).

Authors :: Mellati A
Valizadeh Kiamahalleh M
Dai S
Bi J
Jin B
Zhang H
Source :: Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2016 Feb; Vol. 59, pp. 509-513. Date of Electronic Publication: 2015 Oct 22.
Publication Year :: 2016
Abstract: Poly (N-isopropylacrylamide) (PNIPAAm) is a thermosensitive polymer with various biomedical applications. We examined molecular weight (MW)-dependent cytotoxicity of PNIPAAm. Our results indicated that low-MW PNIPAAm (degree of polymerization (DP)=35) is inherently toxic to cells. Moderate-MW PNIPAAms with their DP between 100 and 200 are non-cytotoxic. When cells are seeded on top of a polymer-coated surface, PNIPAAm with a higher MW (DP=400) shows non/low cytotoxicity, while when monolayer cells are exposed to the polymer solution, cell viability drops drastically. This may be due to lack of nutrient and oxygen rather than intrinsic toxicity of the polymer.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)

Subjects :: Cell Line
Drug Delivery Systems
HEK293 Cells
HeLa Cells
Humans
Molecular Weight
Temperature
Acrylic Resins chemistry
Acrylic Resins toxicity
Cell Survival drug effects

Language :: English
ISSN :: 1873-0191
Volume :: 59
Database :: MEDLINE
Journal :: Materials science & engineering. C, Materials for biological applications
Publication Type :: Academic Journal
Accession number :: 26652402
Full Text :: https://doi.org/10.1016/j.msec.2015.10.043

Full Text Access

Tools