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Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population.
- Source :
-
Virology [Virology] 2016 Jan 15; Vol. 488, pp. 156-61. Date of Electronic Publication: 2015 Nov 30. - Publication Year :
- 2016
-
Abstract
- HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Asian People
Case-Control Studies
China epidemiology
Female
Genetic Variation
Genotyping Techniques
Human papillomavirus 16 isolation & purification
Humans
Middle Aged
Molecular Epidemiology
Papillomavirus Infections epidemiology
Risk Assessment
Genotype
Human papillomavirus 16 classification
Human papillomavirus 16 genetics
Papillomavirus Infections complications
Papillomavirus Infections virology
Uterine Cervical Neoplasms epidemiology
Uterine Cervical Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 488
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 26650690
- Full Text :
- https://doi.org/10.1016/j.virol.2015.11.016