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Comprehensive motion-compensated highly accelerated 4D flow MRI with ferumoxytol enhancement for pediatric congenital heart disease.
- Source :
-
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2016 Jun; Vol. 43 (6), pp. 1355-68. Date of Electronic Publication: 2015 Dec 09. - Publication Year :
- 2016
-
Abstract
- Purpose: To develop and evaluate motion-compensation and compressed-sensing techniques in 4D flow MRI for anatomical assessment in a comprehensive ferumoxytol-enhanced congenital heart disease (CHD) exam.<br />Materials and Methods: A Cartesian 4D flow sequence was developed to enable intrinsic navigation and two variable-density sampling schemes: VDPoisson and VDRad. Four compressed-sensing methods were developed: A) VDPoisson scan reconstructed using spatial wavelets; B) added temporal total variation to A; C) VDRad scan using the same reconstruction as in B; and D) added motion compensation to C. With Institutional Review Board (IRB) approval and Health Insurance Portability and Accountability Act (HIPAA) compliance, 23 consecutive patients (eight females, mean 6.3 years) referred for ferumoxytol-enhanced CHD 3T MRI were recruited. Images were acquired and reconstructed using methods A-D. Two cardiovascular radiologists independently scored the images on a 5-point scale. These readers performed a paired wall motion and functional assessment between method D and 2D balanced steady-state free precession (bSSFP) CINE for 16 cases.<br />Results: Method D had higher diagnostic image quality for most anatomical features (mean 3.8-4.8) compared to A (2.0-3.6), B (2.2-3.7), and C (2.9-3.9) with P < 0.05 with good interobserver agreement (κ ≥ 0.49). Method D had similar or better assessment of myocardial borders and cardiac motion compared to 2D bSSFP (P < 0.05, κ ≥ 0.77). All methods had good internal agreement in comparing aortic with pulmonic flow (BA mean < 0.02%, r > 0.85) and compared to method A (BA mean < 0.13%, r > 0.84) with P < 0.01.<br />Conclusion: Flow, functional, and anatomical assessment in CHD with ferumoxytol-enhanced 4D flow is feasible and can be significantly improved using motion compensation and compressed sensing. J. Magn. Reson. Imaging 2016;43:1355-1368.<br /> (© 2015 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Blood Flow Velocity
Cardiac-Gated Imaging Techniques methods
Child
Child, Preschool
Contrast Media
Coronary Circulation
Female
Humans
Image Enhancement methods
Image Interpretation, Computer-Assisted methods
Infant
Infant, Newborn
Male
Motion
Reproducibility of Results
Sensitivity and Specificity
Young Adult
Artifacts
Ferrosoferric Oxide
Heart Defects, Congenital diagnosis
Heart Defects, Congenital physiopathology
Imaging, Three-Dimensional methods
Magnetic Resonance Angiography methods
Magnetic Resonance Imaging, Cine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 43
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 26646061
- Full Text :
- https://doi.org/10.1002/jmri.25106