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Therapeutic Effect of Metformin on Chemerin in Non-Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD).
- Source :
-
Clinical laboratory [Clin Lab] 2015; Vol. 61 (10), pp. 1409-14. - Publication Year :
- 2015
-
Abstract
- Background: Chemerin is an important risk factor of insulin resistance. Non-alcoholic fatty liver has typical characteristics of insulin resistance. The aim of this study was to explore the potential role of chemerin in NAFLD.<br />Methods: 45 subjects included 22 control subjects (A group) and 23 subjects diagnosed with non-alcoholic fatty liver disease (B group) participated in the study. 23 patients in the NAFLD group received oral daily metformin at a dose of 20 mg/kg/day for 24 weeks follow-up. Chemerin and insulin resistance markers were determined at baseline and 24 weeks.<br />Results: The levels of WHR, BMI, FINS, HOMA-IR, TG, ALT, AST, and Chemerin in B group were significantly higher than A group. After 24 weeks of metformin treatment, the levels of WHR, AST, ALT, TG, chemerin and HOMA-IR were significantly reduced (p < 0.05) and other indexes were not changed significantly. Correlation analysis indicated that serum chemerin concentrations were positively correlated with BMI, WHR, HOMA-IR, FINS, TG, ALT, and AST levels. Logistic regression analysis showed chemerin, TG, and ALT were independent variables associated with NAFLD.<br />Conclusions: These findings showed a significant increase of chemerin level in NAFLD patients. Metformin treatment can improve NAFLD and decrease the level of chemerin. Chemerin, TG, and ALT were independent variables associated with NAFLD.
- Subjects :
- Administration, Oral
Adult
Biomarkers metabolism
Blood Pressure
Drug Synergism
Female
Humans
Hypoglycemic Agents therapeutic use
Insulin chemistry
Insulin Resistance
Logistic Models
Male
Middle Aged
Risk Factors
Chimerin 1 metabolism
Metformin therapeutic use
Non-alcoholic Fatty Liver Disease drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1433-6510
- Volume :
- 61
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical laboratory
- Publication Type :
- Academic Journal
- Accession number :
- 26642701
- Full Text :
- https://doi.org/10.7754/clin.lab.2015.150211