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Subjective Memory Complaints in APOEɛ4 Carriers are Associated with High Amyloid-β Burden.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016; Vol. 49 (4), pp. 1115-22. - Publication Year :
- 2016
-
Abstract
- Background: APOEɛ4 genotype and aging have been identified as risk factors for Alzheimer's disease (AD). In addition, subjective memory complaints (SMC) might be a first clinical expression of the effect of AD pathology on cognitive functioning.<br />Objective: To assess whether APOEɛ4 genotype, age, SMC, and episodic memory are risk factors for high amyloid-β (Aβ) burden in cognitively normal elderly.<br />Methods: 307 cognitively normal participants (72.7 ± 6.8 years, 53% female, 55% SMC) from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent amyloid PET and APOE genotyping. Logistic regression analyses were performed to determine the association of APOEɛ4 genotype, age, SMC, and episodic memory with Aβ pathology.<br />Results: Odds of high Aβ burden were greater at an older age (OR = 3.21; 95% CI = 1.68-6.14), when SMC were present (OR = 1.90; 95% CI = 1.03-3.48), and for APOEɛ4 carriers (OR = 7.49; 95% CI = 3.96-14.15), while episodic memory was not associated with odds of high Aβ burden. Stratified analyses showed that odds of SMC for high Aβ burden were increased in specifically APOEɛ4 carriers (OR = 4.58, 95% CI = 1.83-11.49) and younger participants (OR = 3.73, 95% CI = 1.39-10.01).<br />Conclusion: Aging, APOEɛ4 genotype, and SMC were associated with high Aβ burden. SMC were especially indicative of high Aβ burden in younger participants and in APOEɛ4 carriers. These findings suggest that selection based on the presence of SMC, APOEɛ4 genotype and age may help identify healthy elderly participants with high Aβ burden eligible for secondary prevention trials.
- Subjects :
- Aged
Aging genetics
Aging metabolism
Aging psychology
Aniline Compounds
Benzothiazoles
Brain diagnostic imaging
Cognition Disorders diagnostic imaging
Cognition Disorders psychology
Female
Genotyping Techniques
Humans
Logistic Models
Male
Neuropsychological Tests
Positron-Emission Tomography
Radiopharmaceuticals
Thiazoles
Amyloid beta-Peptides metabolism
Apolipoprotein E4 genetics
Brain metabolism
Cognition Disorders genetics
Cognition Disorders metabolism
Heterozygote
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 49
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 26639956
- Full Text :
- https://doi.org/10.3233/JAD-150446