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Statins and atherosclerosis: the role of epigenetics.
- Source :
-
Medwave [Medwave] 2015 Nov 26; Vol. 15 (10), pp. e6324. Date of Electronic Publication: 2015 Nov 26. - Publication Year :
- 2015
-
Abstract
- Atherosclerosis is an immune-inflammatory disease, in which pathophysiological mechanisms include inflammation patterns and epigenetic changes that alter gene expression of several inflammatory and non-inflammatory mediators. Epigenetics is offering explanations on how diet, environmental factors and lifestyle can influence the onset and progression of the disease, and how these alterations can be transmitted to the following generations without any changes in DNA sequences. Statins, through their pleiotropic effects, provide a useful tool in controlling the progression of plaques and their subsequent impact.
- Subjects :
- Atherosclerosis genetics
Atherosclerosis pathology
Base Sequence
Disease Progression
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology
Inflammation drug therapy
Inflammation genetics
Inflammation pathology
Plaque, Atherosclerotic drug therapy
Plaque, Atherosclerotic pathology
Atherosclerosis drug therapy
Epigenesis, Genetic
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 0717-6384
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Medwave
- Publication Type :
- Academic Journal
- Accession number :
- 26639162
- Full Text :
- https://doi.org/10.5867/medwave.2015.10.6324