Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells.

Authors :: Weiler AM
Das A
Akinyosoye O
Cui S
O'Connor SL
Scheef EA
Reed JS
Panganiban AT
Sacha JB
Rakasz EG
Friedrich TC
Maness NJ
Source :: Journal of virology [J Virol] 2015 Dec 04; Vol. 90 (4), pp. 2119-26. Date of Electronic Publication: 2015 Dec 04 (Print Publication: 2016).
Publication Year :: 2015
Abstract: Nef-specific CD8(+) T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef165-173IW9 epitope revealed highly restricted evolution. A common acute escape variant, T170I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Subjects :: Animals
High-Throughput Nucleotide Sequencing
Macaca
Viral Regulatory and Accessory Proteins immunology
CD8-Positive T-Lymphocytes immunology
Epitopes, T-Lymphocyte genetics
Epitopes, T-Lymphocyte immunology
Histocompatibility Antigens Class I metabolism
Mutation, Missense
Viral Regulatory and Accessory Proteins genetics
Viral Regulatory and Accessory Proteins metabolism

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