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The soluble receptor ST2 is positively associated with occupational exposure to radiation.
- Source :
-
International journal of radiation biology [Int J Radiat Biol] 2016; Vol. 92 (2), pp. 87-93. Date of Electronic Publication: 2015 Dec 03. - Publication Year :
- 2016
-
Abstract
- Purpose Radiation exposure, besides the risk of cancer, may also increase the risk of non-cancer diseases, including cardiovascular disease (CVD). This study investigates whether the soluble form of the ST2 receptor (sST2), an emerging prognostic marker in patients with CVD, can be used to monitor the CVD risk in individuals occupationally exposed to radiation. Materials and methods sST2 in blood plasma from 69 individuals, 45 workers from the nuclear industry and 24 controls, was analyzed using enzyme-linked assay (ELISA). Total antioxidant status (TAS) of blood plasma and levels of reactive oxygen species (ROS) in lymphocytes were determined by colorimetric and fluorescence assays. Results The data suggest a 5-fold increase in the number of subjects with sST2 levels above the clinical threshold and a 10-fold increase in the number of subjects with TAS levels outside the reference range in the exposed group when compared to the group of non-exposed individuals. The strongest up-regulation of TAS was measured in the group of younger workers with cumulative doses not exceeding 50 mSv. Conclusion The present study may represent an initial step towards the establishment of sST2 as a biomarker for CVD risk estimation in the context of radiation exposure.
- Subjects :
- Absorption, Radiation
Adult
Biomarkers blood
Cells, Cultured
Dose-Response Relationship, Radiation
Female
Humans
Interleukin-1 Receptor-Like 1 Protein
Male
Middle Aged
Radiation Dosage
Lymphocytes metabolism
Lymphocytes radiation effects
Occupational Exposure analysis
Radiation Exposure analysis
Reactive Oxygen Species blood
Receptors, Cell Surface blood
Subjects
Details
- Language :
- English
- ISSN :
- 1362-3095
- Volume :
- 92
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of radiation biology
- Publication Type :
- Academic Journal
- Accession number :
- 26634771
- Full Text :
- https://doi.org/10.3109/09553002.2016.1115135