Back to Search
Start Over
Interferon response of the cystic fibrosis bronchial epithelium to major and minor group rhinovirus infection.
- Source :
-
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2016 May; Vol. 15 (3), pp. 332-9. Date of Electronic Publication: 2015 Nov 21. - Publication Year :
- 2016
-
Abstract
- Rhinoviruses (RVs) are associated with exacerbations of cystic fibrosis (CF), asthma and COPD. There is growing evidence suggesting the involvement of the interferon (IFN) pathway in RV-associated morbidity in asthma and COPD. The mechanisms of RV-triggered exacerbations in CF are poorly understood. In a pilot study, we assessed the antiviral response of CF and healthy bronchial epithelial cells (BECs) to RV infection, we measured the levels of IFNs, pattern recognition receptors (PRRs) and IFN-stimulated genes (ISGs) upon infection with major and minor group RVs and poly(IC) stimulation. Major group RV infection of CF BECs resulted in a trend towards a diminished IFN response at the level of IFNs, PRRs and ISGs in comparison to healthy BECs. Contrary to major group RV, the IFN pathway induction upon minor group RV infection was significantly increased at the level of IFNs and PRRs in CF BECs compared to healthy BECs.<br /> (Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Culture Techniques
Humans
Immunity, Mucosal
Interferon Inducers immunology
Cystic Fibrosis complications
Cystic Fibrosis immunology
Cystic Fibrosis virology
Interferons analysis
Picornaviridae Infections complications
Picornaviridae Infections immunology
Respiratory Mucosa immunology
Rhinovirus immunology
Rhinovirus isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5010
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
- Publication Type :
- Academic Journal
- Accession number :
- 26613982
- Full Text :
- https://doi.org/10.1016/j.jcf.2015.10.013