Back to Search
Start Over
Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.
- Source :
-
The EMBO journal [EMBO J] 2016 Jan 04; Vol. 35 (1), pp. 89-101. Date of Electronic Publication: 2015 Nov 26. - Publication Year :
- 2016
-
Abstract
- Multiple sclerosis is the most frequent chronic inflammatory disease of the CNS. The entry and survival of pathogenic T cells in the CNS are crucial for the initiation and persistence of autoimmune neuroinflammation. In this respect, contradictory evidence exists on the role of the most potent type of antigen-presenting cells, dendritic cells. Applying intravital two-photon microscopy, we demonstrate the gatekeeper function of CNS professional antigen-presenting CD11c(+) cells, which preferentially interact with Th17 cells. IL-17 expression correlates with expression of GM-CSF by T cells and with accumulation of CNS CD11c(+) cells. These CD11c(+) cells are organized in perivascular clusters, targeted by T cells, and strongly express the inflammatory chemokines Ccl5, Cxcl9, and Cxcl10. Our findings demonstrate a fundamental role of CNS CD11c(+) cells in the attraction of pathogenic T cells into and their survival within the CNS. Depletion of CD11c(+) cells markedly reduced disease severity due to impaired enrichment of pathogenic T cells within the CNS.<br /> (© 2015 The Authors.)
- Subjects :
- Animals
Antigen-Presenting Cells chemistry
Brain immunology
Cell Movement
Dendritic Cells chemistry
Encephalomyelitis, Autoimmune, Experimental immunology
Granulocyte-Macrophage Colony-Stimulating Factor metabolism
Interleukin-17 metabolism
Mice, Inbred C57BL
T-Lymphocytes physiology
Th17 Cells physiology
Antigen-Presenting Cells physiology
Brain pathology
CD11c Antigen analysis
Dendritic Cells physiology
Encephalomyelitis, Autoimmune, Experimental pathology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2075
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The EMBO journal
- Publication Type :
- Academic Journal
- Accession number :
- 26612827
- Full Text :
- https://doi.org/10.15252/embj.201591488