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Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1.
- Source :
-
Structure (London, England : 1993) [Structure] 2015 Dec 01; Vol. 23 (12), pp. 2341-2348. Date of Electronic Publication: 2015 Oct 22. - Publication Year :
- 2015
-
Abstract
- Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has recently provided breakthrough progress in the treatment of melanoma, non-small cell lung cancer, and other types of cancer. Small-molecule drugs interfering with this pathway are highly awaited, but their development is hindered by insufficient structural information. This study reveals the molecular details of the human PD-1/PD-L1 interaction based on an X-ray structure of the complex. First, it is shown that the ligand binding to human PD-1 is associated with significant plasticity within the receptor. Second, a detailed molecular map of the interaction surface is provided, allowing definition of the regions within both interacting partners that may likely be targeted by small molecules.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-4186
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Structure (London, England : 1993)
- Publication Type :
- Academic Journal
- Accession number :
- 26602187
- Full Text :
- https://doi.org/10.1016/j.str.2015.09.010