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Breast Cancer-Derived Extracellular Vesicles: Characterization and Contribution to the Metastatic Phenotype.
- Source :
-
BioMed research international [Biomed Res Int] 2015; Vol. 2015, pp. 634865. Date of Electronic Publication: 2015 Oct 27. - Publication Year :
- 2015
-
Abstract
- The study of extracellular vesicles (EVs) in cancer progression is a complex and rapidly evolving field. Whole categories of cellular interactions in cancer which were originally presumed to be due solely to soluble secreted molecules have now evolved to include membrane-enclosed extracellular vesicles (EVs), which include both exosomes and shed microvesicles (MVs), and can contain many of the same molecules as those secreted in soluble form but many different molecules as well. EVs released by cancer cells can transfer mRNA, miRNA, and proteins to different recipient cells within the tumor microenvironment, in both an autocrine and paracrine manner, causing a significant impact on signaling pathways, mRNA transcription, and protein expression. The transfer of EVs to target cells, in turn, supports cancer growth, immunosuppression, and metastasis formation. This review focuses exclusively on breast cancer EVs with an emphasis on breast cancer-derived exosomes, keeping in mind that breast cancer-derived EVs share some common physical properties with EVs of other cancers.
- Subjects :
- Breast Neoplasms pathology
Cell-Derived Microparticles pathology
Exosomes pathology
Female
Humans
MicroRNAs metabolism
Neoplasm Metastasis
Neoplasm Proteins metabolism
RNA, Neoplasm metabolism
RNA, Transfer metabolism
Tumor Microenvironment
Breast Neoplasms metabolism
Cell-Derived Microparticles metabolism
Exosomes metabolism
Gene Expression Regulation, Neoplastic
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 2314-6141
- Volume :
- 2015
- Database :
- MEDLINE
- Journal :
- BioMed research international
- Publication Type :
- Academic Journal
- Accession number :
- 26601108
- Full Text :
- https://doi.org/10.1155/2015/634865