Limited Prognostic Value of SUV max Measured by F-18 FDG PET/CT in Newly Diagnosed Small Cell Lung Cancer Patients.

Authors :: Kim SJ
Chang S
Source :: Oncology research and treatment [Oncol Res Treat] 2015; Vol. 38 (11), pp. 577-85. Date of Electronic Publication: 2015 Oct 21.
Publication Year :: 2015
Abstract: Background: The purpose of this study was to evaluate the prognostic value of the maximum standard uptake value (SUV max) measured by 18-F fluoro-2-deoxy-d-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in newly diagnosed small cell lung cancer (SCLC) patients.<br />Methods: We reviewed the medical records of newly diagnosed SCLC patients who were given a histological diagnosis from June 2008 to June 2014. 82 patients who satisfied the inclusion criteria were enrolled for final analysis (male n = 75, female n = 7). The relationship between SUV max and overall survival (OS) and progression-free survival (PFS) was evaluated.<br />Results: Median follow-up was 25.0 months (range 11.6-55.5 months). The median OS was 11.2 months (range 1.6-55.5 months), and the median PFS was 6.1 months (range 0.9-55.5 months). Survival analysis showed no statistical differences in OS and PFS between high and low SUV max groups.<br />Conclusion: This study does not support the use of SUV max of pretreatment F-18 FDG PET/CT scans as a prognostic tool for patients with SCLC.<br /> (© 2015 S. Karger GmbH, Freiburg.)

Subjects :: Adult
Aged
Aged, 80 and over
Algorithms
Carcinoma, Non-Small-Cell Lung metabolism
Computer Simulation
Disease-Free Survival
Early Detection of Cancer methods
Early Detection of Cancer statistics & numerical data
Female
Fluorodeoxyglucose F18 pharmacokinetics
Humans
Image Interpretation, Computer-Assisted methods
Lung Neoplasms metabolism
Male
Middle Aged
Models, Biological
Multimodal Imaging methods
Multimodal Imaging statistics & numerical data
Positron-Emission Tomography methods
Prevalence
Prognosis
Radiopharmaceuticals pharmacokinetics
Reproducibility of Results
Republic of Korea epidemiology
Risk Assessment methods
Risk Factors
Sensitivity and Specificity
Survival Rate
Tomography, X-Ray Computed methods
Carcinoma, Non-Small-Cell Lung diagnosis
Carcinoma, Non-Small-Cell Lung mortality
Lung Neoplasms diagnosis
Lung Neoplasms mortality
Positron-Emission Tomography statistics & numerical data
Tomography, X-Ray Computed statistics & numerical data

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