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Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2015 Dec 09; Vol. 7 (48), pp. 26400-4. Date of Electronic Publication: 2015 Nov 25. - Publication Year :
- 2015
-
Abstract
- Implantation of sustained antibacterial system after abdominal surgery could effectively prevent complicated intra-abdominal infection. In this study, a simple blended electrospun membrane made of poly(D,L-lactic-co-glycolide) (PLGA)/poly(dioxanone) (PDO)/Ciprofloxacin hydrochloride (CiH) could easily result in approximately linear drug release profile and sustained antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The addition of PDO changed the stack structure of PLGA, which in turn influenced the fiber swelling and created drug diffusion channels. It could be a good candidate for reducing postoperative infection or be associated with other implant to resist biofilm formation.
- Subjects :
- Anti-Bacterial Agents chemistry
Ciprofloxacin chemistry
Delayed-Action Preparations
Membranes, Artificial
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
Polylactic Acid-Polyglycolic Acid Copolymer
Staphylococcus aureus drug effects
Anti-Bacterial Agents pharmacology
Ciprofloxacin pharmacology
Lactic Acid chemistry
Polydioxanone chemistry
Polyglycolic Acid chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 7
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Report
- Accession number :
- 26596498
- Full Text :
- https://doi.org/10.1021/acsami.5b09820