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Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects.

Authors :
Zhang Z
Tang J
Wang H
Xia Q
Xu S
Han CC
Source :
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2015 Dec 09; Vol. 7 (48), pp. 26400-4. Date of Electronic Publication: 2015 Nov 25.
Publication Year :
2015

Abstract

Implantation of sustained antibacterial system after abdominal surgery could effectively prevent complicated intra-abdominal infection. In this study, a simple blended electrospun membrane made of poly(D,L-lactic-co-glycolide) (PLGA)/poly(dioxanone) (PDO)/Ciprofloxacin hydrochloride (CiH) could easily result in approximately linear drug release profile and sustained antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The addition of PDO changed the stack structure of PLGA, which in turn influenced the fiber swelling and created drug diffusion channels. It could be a good candidate for reducing postoperative infection or be associated with other implant to resist biofilm formation.

Details

Language :
English
ISSN :
1944-8252
Volume :
7
Issue :
48
Database :
MEDLINE
Journal :
ACS applied materials & interfaces
Publication Type :
Report
Accession number :
26596498
Full Text :
https://doi.org/10.1021/acsami.5b09820