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Prevention of invasive bacterial diseases by immunization with polysaccharide-protein conjugates.
- Source :
-
Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 1989; Vol. 146, pp. 169-80. - Publication Year :
- 1989
-
Abstract
- Covalent binding of CPS to T cell-dependent carrier proteins to form conjugates can be done by clinically acceptable methods. As a component of a conjugate, two immunologic properties of CPS are changed: 1) their immunogenicity is increased and; 2) reinjection induces a booster response in the young (T cell-dependence). Serum antibodies induced by the CPS alone, or as a component of a conjugate, are qualitatively similar: the difference between antibodies elicited by the CPS or the conjugate is quantitative. A clinical trial with a Hib-DT conjugate showed that conjugates could confer immunity in an age group not protected by the CPS alone. (table; see text) Induction of serum CPS antibodies confers protection against capsulated bacteria in the bloodstream: their role in the interaction of these pathogens on the mucous membranes has not been characterized. Preliminary in vitro experiments suggest that secretory antibodies to non-capsular structures may also exert protective immunity.
- Subjects :
- Animals
Bacterial Vaccines administration & dosage
Carrier Proteins administration & dosage
Carrier Proteins immunology
Humans
Immunization
Mucous Membrane immunology
Polysaccharides, Bacterial administration & dosage
Bacterial Infections prevention & control
Polysaccharides, Bacterial immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0070-217X
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Current topics in microbiology and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 2659266
- Full Text :
- https://doi.org/10.1007/978-3-642-74529-4_18