Back to Search
Start Over
CD4 + T helper cell responses to NY-ESO-1 tumor antigen in ovarian cancer resist perversion into immunosuppressive Tregs.
- Source :
-
Oncoimmunology [Oncoimmunology] 2014 Oct 31; Vol. 4 (12), pp. e946370. Date of Electronic Publication: 2014 Oct 31 (Print Publication: 2015). - Publication Year :
- 2014
-
Abstract
- In a recent study, we have demonstrated that T helper type 1 (T <subscript>H</subscript> 1) cells specific for the tumor antigen NY-ESO-1 are amplified at ovarian tumor sites but are not "perverted" into immunosuppressive FOXP3 <superscript>+</superscript> regulatory T cells (Tregs). These findings encourage the development of protocols aiming to eliminate, or inactivate, FOXP3 <superscript>+</superscript> Tregs and reinforce Type I anticancer immunity, to improve clinical outcomes.
Details
- Language :
- English
- ISSN :
- 2162-4011
- Volume :
- 4
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Oncoimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 26587312
- Full Text :
- https://doi.org/10.4161/21624011.2014.946370