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[Economic impact of lung cancer screening in France: A modeling study].
- Source :
-
Revue des maladies respiratoires [Rev Mal Respir] 2017 Sep; Vol. 34 (7), pp. 717-728. Date of Electronic Publication: 2015 Nov 12. - Publication Year :
- 2017
-
Abstract
- Introduction: The National Lung Screening Trial found that, in a selected population with a high risk of lung cancer, an annual low-dose CT-scan decreased lung cancer mortality by 20% and overall mortality by 7% compared to annual chest X-Ray. In France, a work group stated that individual screening should be considered in this setting. However, the economic impact of an organized and generalized (to all eligible individuals) screening in France was never reported.<br />Methods: This is a modeling study using French population demographic data and published data from randomized screening trials. We used the same selection criteria as NLST: 55-74-year-old smokers for at least 30 pack-years, current smoker or quit less than 15 years. We computed a second model including also 50-54-year-old individuals. Then, we used different participation rates: 65%, 45%, and 32%.<br />Results: According to the considered model, there would be 1,650,588 to 2,283,993 subjects eligible to screening in France. According to the model and participation rate, lung cancer screening would diagnose 3600 to 10,118 stages 1/2 lung cancer each year. There would be 5991 to 16,839 false-positives, of whom 1416 to 3981 would undergo unnecessary surgery. Screening policy would cost 105 to 215 € million per year. However, increasing the price of a cigarette pack by 0.05 to 0.10 € would fully cover the screening costs.<br />Conclusion: Participation rate is a key point for screening impact. Screening could be easily funded by a small increase in cigarette prices.<br /> (Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Aged
Cost-Benefit Analysis
Early Detection of Cancer methods
Early Detection of Cancer statistics & numerical data
Female
France epidemiology
Humans
Lung Neoplasms economics
Lung Neoplasms epidemiology
Male
Mass Screening economics
Mass Screening methods
Mass Screening statistics & numerical data
Middle Aged
Patient Participation
Radiography, Thoracic economics
Radiography, Thoracic statistics & numerical data
Smoking epidemiology
Tomography, X-Ray Computed economics
Tomography, X-Ray Computed statistics & numerical data
Unnecessary Procedures economics
Unnecessary Procedures statistics & numerical data
Early Detection of Cancer economics
Lung Neoplasms diagnosis
Models, Economic
Subjects
Details
- Language :
- French
- ISSN :
- 1776-2588
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Revue des maladies respiratoires
- Publication Type :
- Academic Journal
- Accession number :
- 26585377
- Full Text :
- https://doi.org/10.1016/j.rmr.2015.10.004