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Association of Cross-Sectional and Longitudinal Change in Arterial Stiffness With Gene Expression in the Twins UK Cohort.
- Source :
-
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2016 Jan; Vol. 67 (1), pp. 70-6. Date of Electronic Publication: 2015 Nov 16. - Publication Year :
- 2016
-
Abstract
- We investigated whether expression of genes previously implicated in arterial stiffening associates with cross-sectional and longitudinal measures of arterial stiffness. Women from the Twins UK cohort (n=470, aged 39-81 years) had gene expression in lymphoblastoid cell lines measured using an Illumina microarray. Arterial stiffness was measured by carotid-femoral pulse wave velocity and carotid distensibility. A subsample (n=121) of women had repeat vascular measures after a mean±SD follow-up of 4.3±1.4 years. Associations of arterial phenotypes with gene expression levels were examined for 52 genes identified from previous association studies. The gene transcript most closely associated with pulse wave velocity in cross-sectional analysis was ectonucleotide pyrophosphatase/phosphodiesterase (P=0.012). Pleiotropic genetic effects accounted for 14% of the phenotypic correlation between ectonucleotide pyrophosphatase/phosphodiesterase expression and pulse wave velocity. Progression of pulse wave velocity during the follow-up period best related to expression of ectonucleotide pyrophosphatase/phosphodiesterase (β=0.19, P=0.008) and collagen type IV α 1 (β=0.32, P<0.0001). Gene transcripts most closely related to change in carotid distensibility during the follow-up period were endothelial nitric oxide synthase (β=-0.20, P=0.005), angiotensin-converting enzyme (β=-0.15, P=0.035), and B-cell CLL/lymphoma11B (β=0.18, P=0.010). Expression levels of angiotensin-converting enzyme also related to progression in carotid diameter (β=0.21, P=0.012). Expression levels of ectonucleotide pyrophosphatase/phosphodiesterase, involved in arterial calcification, and collagen type IV α 1, involved in collagen formation, correlate with aortic stiffening. These genes may be functional mediators of arterial stiffening.<br /> (© 2015 American Heart Association, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Arteriosclerosis diagnostic imaging
Arteriosclerosis physiopathology
Carotid Arteries diagnostic imaging
Carotid Arteries physiopathology
Cross-Sectional Studies
Female
Femoral Artery diagnostic imaging
Femoral Artery physiopathology
Follow-Up Studies
Humans
Male
Middle Aged
Pulse Wave Analysis
Ultrasonography
United Kingdom
Arteriosclerosis genetics
Blood Pressure physiology
Gene Expression
Twins genetics
Vascular Stiffness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4563
- Volume :
- 67
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Publication Type :
- Academic Journal
- Accession number :
- 26573706
- Full Text :
- https://doi.org/10.1161/HYPERTENSIONAHA.115.05802