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Evaluation of a Congenital Infantile Fibrosarcoma by Comprehensive Genomic Profiling Reveals an LMNA-NTRK1 Gene Fusion Responsive to Crizotinib.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 2015 Nov 12; Vol. 108 (1). Date of Electronic Publication: 2015 Nov 12 (Print Publication: 2016). - Publication Year :
- 2015
- Subjects :
- Antineoplastic Agents administration & dosage
Crizotinib
Fibrosarcoma congenital
Fibrosarcoma pathology
Fibrosarcoma surgery
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Infant
Lung Neoplasms drug therapy
Lung Neoplasms secondary
Molecular Targeted Therapy
Protein Kinase Inhibitors administration & dosage
Pyrazoles administration & dosage
Pyridines administration & dosage
Reverse Transcriptase Polymerase Chain Reaction
Spinal Neoplasms drug therapy
Spinal Neoplasms secondary
Treatment Outcome
Antineoplastic Agents pharmacology
Fibrosarcoma drug therapy
Fibrosarcoma genetics
Gene Fusion
Lamin Type A genetics
Protein Kinase Inhibitors pharmacology
Pyrazoles pharmacology
Pyridines pharmacology
Receptor, trkA genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2105
- Volume :
- 108
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Report
- Accession number :
- 26563356
- Full Text :
- https://doi.org/10.1093/jnci/djv307