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Relationship Between Cerebrovascular Risk, Cognition, and Treatment Outcome in Late-Life Psychotic Depression.
- Source :
-
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2015 Dec; Vol. 23 (12), pp. 1270-1275. Date of Electronic Publication: 2015 Aug 20. - Publication Year :
- 2015
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Abstract
- Objective: To examine whether cerebrovascular risk, executive function, and processing speed are associated with acute treatment outcome of psychotic depression in older adults.<br />Methods: The authors analyzed data from 142 persons aged 60 years or older with major depression with psychotic features who participated in a 12-week randomized controlled trial (RCT) comparing olanzapine plus sertraline with olanzapine plus placebo. The independent variables were baseline cerebrovascular risk (Framingham Stroke Risk Score), baseline executive function (Stroop interference score and the initiation/perseveration subscale of the Mattis Dementia Rating Scale), and baseline processing speed (color and word reading components of the Stroop). The outcome variable was change in severity of depression, measured by the 17-item Hamilton Depression Rating Scale total score, during the course of the RCT.<br />Results: Greater baseline cerebrovascular risk was significantly associated with less improvement in depression severity over time, after controlling for pertinent covariates. Neither executive function nor processing speed predicted outcome.<br />Conclusion: This study suggests an association of cerebrovascular risk, but not executive function or processing speed, with treatment outcome of major depression with psychotic features in older adults.<br /> (Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Antidepressive Agents therapeutic use
Antipsychotic Agents therapeutic use
Cerebrovascular Disorders psychology
Cognition drug effects
Cognition Disorders psychology
Depressive Disorder, Major psychology
Double-Blind Method
Executive Function drug effects
Humans
Mental Processes drug effects
Middle Aged
Neuropsychological Tests
Olanzapine
Psychiatric Status Rating Scales
Psychotic Disorders complications
Psychotic Disorders drug therapy
Psychotic Disorders psychology
Reaction Time drug effects
Risk
Severity of Illness Index
Stroop Test
Treatment Outcome
Young Adult
Benzodiazepines therapeutic use
Cerebrovascular Disorders complications
Cognition Disorders complications
Depressive Disorder, Major complications
Depressive Disorder, Major drug therapy
Sertraline therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1545-7214
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 26560512
- Full Text :
- https://doi.org/10.1016/j.jagp.2015.08.002