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Neuroendocrine differentiation: The mysterious fellow of colorectal cancer.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 Nov 07; Vol. 21 (41), pp. 11740-7. - Publication Year :
- 2015
-
Abstract
- Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since decades, but its clinical impact is still controversially discussed. Detailed parameter analyses hint at the possibility that probably not neuroendocrine differentiation itself, but its association with poor grade of tumor differentiation, lymph node metastases, distant metastases and other unfavorable features contribute to worse clinical outcome. However, other studies deny a relationship between neuroendocrine differentiation and prognosis of colorectal cancer. This review elucidates, whether new insights into the origin of neuroendocrine differentiation in the intestinal epithelium, its regulation by mTOR pathway components and its possible link to the intestinal stem cell compartment could determine a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer.
- Subjects :
- Animals
Biomarkers metabolism
Cell Lineage
Colorectal Neoplasms epidemiology
Colorectal Neoplasms metabolism
Colorectal Neoplasms therapy
Enteroendocrine Cells metabolism
Humans
Intestinal Mucosa metabolism
Neoplastic Stem Cells metabolism
Neuroendocrine Tumors epidemiology
Neuroendocrine Tumors metabolism
Neuroendocrine Tumors therapy
Phenotype
Prognosis
Signal Transduction
Cell Differentiation
Colorectal Neoplasms pathology
Enteroendocrine Cells pathology
Intestinal Mucosa pathology
Neoplastic Stem Cells pathology
Neuroendocrine Tumors pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 26556999
- Full Text :
- https://doi.org/10.3748/wjg.v21.i41.11740