Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide.

Authors :: Goldstein AL
Low TL
McAdoo M
McClure J
Thurman GB
Rossio J
Lai CY
Chang D
Wang SS
Harvey C
Ramel AH
Meienhofer J
Source :: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1977 Feb; Vol. 74 (2), pp. 725-9.
Publication Year :: 1977
Abstract: The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.

Subjects :: Amino Acid Sequence
Amino Acids analysis
Animals
Biological Assay
Cattle
Chymotrypsin
Peptide Fragments analysis
Thermolysin
Thymus Gland
Trypsin
Thymosin immunology
Thymosin isolation & purification
Thymus Hormones immunology

Language :: English
ISSN :: 0027-8424
Volume :: 74
Issue :: 2
Database :: MEDLINE
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 265536
Full Text :: https://doi.org/10.1073/pnas.74.2.725

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