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Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.
- Source :
-
Cell metabolism [Cell Metab] 2015 Dec 01; Vol. 22 (6), pp. 971-82. Date of Electronic Publication: 2015 Nov 06. - Publication Year :
- 2015
-
Abstract
- The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Animals
Bacteroides genetics
Bacteroides growth & development
Bacteroides physiology
Blood Glucose analysis
Cross-Over Studies
Feces microbiology
Female
Glycogen metabolism
Humans
Hydrogen metabolism
Insulin blood
Intestines microbiology
Liver metabolism
Male
Mice
Mice, Inbred C57BL
Middle Aged
Prevotella genetics
Prevotella physiology
RNA, Ribosomal, 16S chemistry
RNA, Ribosomal, 16S metabolism
Dietary Fiber pharmacology
Glucose metabolism
Microbiota drug effects
Prevotella growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1932-7420
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cell metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 26552345
- Full Text :
- https://doi.org/10.1016/j.cmet.2015.10.001