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High rate of HTLV-II infection in seropositive i.v. drug abusers in New Orleans.
- Source :
-
Science (New York, N.Y.) [Science] 1989 Apr 28; Vol. 244 (4903), pp. 471-5. - Publication Year :
- 1989
-
Abstract
- Confirmed infection with HTLV-II (human T cell leukemia virus type II) has been described only in rare cases. The major limitation to serological diagnosis of HTLV-II has been the difficulty of distinguishing HTLV-II from HTLV-I (human T cell leukemia virus type I) infection, because of substantial cross-reactivity between the viruses. A sensitive modification of the polymerase chain reaction method was used to provide unambiguous molecular evidence that a significant proportion of intravenous drug abusers are infected with HTLV, and the majority of these individuals are infected with HTLV-II rather than HTLV-I. Of 23 individuals confirmed by polymerase chain reaction analysis to be infected with HTLV, 21 were identified to be infected with HTLV-II, and 2 were infected with HTLV-I. Molecular identification of an HTLV-II--infected population provides an opportunity to investigate the pathogenicity of HTLV-II in humans.
- Subjects :
- Base Sequence
DNA, Viral analysis
DNA-Directed DNA Polymerase
Genes, Viral
HTLV-I Antibodies analysis
HTLV-I Infections diagnosis
HTLV-I Infections epidemiology
HTLV-I Infections etiology
HTLV-II Infections diagnosis
HTLV-II Infections etiology
Human T-lymphotropic virus 1 genetics
Human T-lymphotropic virus 1 immunology
Human T-lymphotropic virus 2 genetics
Human T-lymphotropic virus 2 immunology
Humans
Immunoblotting
Immunoenzyme Techniques
Louisiana
Molecular Sequence Data
Sequence Homology, Nucleic Acid
HTLV-II Antibodies analysis
HTLV-II Infections epidemiology
Substance-Related Disorders complications
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 244
- Issue :
- 4903
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 2655084
- Full Text :
- https://doi.org/10.1126/science.2655084