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Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans.
- Source :
-
Age (Dordrecht, Netherlands) [Age (Dordr)] 2015 Dec; Vol. 37 (6), pp. 113. Date of Electronic Publication: 2015 Nov 06. - Publication Year :
- 2015
-
Abstract
- Folic acid (FA) is an essential nutrient that the human body needs but cannot be synthesized on its own. Fortified foods and plant food sources such as green leafy vegetables, beans, fruits, and juices are good sources of FA to meet the daily requirements of the body. The aim was to evaluate the effect of dietary FA levels on the longevity of well-known experimental aging model Caenorhabditis elegans. Here, we show for first time that FA extends organism life span and causes a delay in aging. We observed that FA inhibits mechanistic target of rapamycin (mTOR) and insulin/insulin growth factor 1 (IGF-1) signaling pathways to control both oxidative stress levels and life span. The expression levels of stress- and life span-relevant gerontogenes, viz. daf-16, skn-1, and sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to attenuate the intracellular reactive oxygen species (ROS) damage and to delay the aging process. Our study promotes the use of FA to mitigate abiotic stresses and other aging-related ailments.<br />Competing Interests: The authors declare that they have no competing interests.
- Subjects :
- Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins metabolism
DNA-Binding Proteins metabolism
Forkhead Transcription Factors metabolism
Glutathione Transferase metabolism
Insulin metabolism
Insulin-Like Growth Factor I metabolism
Microscopy, Fluorescence
Models, Animal
Oxidation-Reduction
Real-Time Polymerase Chain Reaction
Signal Transduction
Sirtuins metabolism
Superoxide Dismutase metabolism
TOR Serine-Threonine Kinases metabolism
Transcription Factors metabolism
Aging drug effects
Folic Acid administration & dosage
Folic Acid pharmacology
Longevity drug effects
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1574-4647
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Age (Dordrecht, Netherlands)
- Publication Type :
- Academic Journal
- Accession number :
- 26546011
- Full Text :
- https://doi.org/10.1007/s11357-015-9850-5