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Nanoencapsulated curcumin and praziquantel treatment reduces periductal fibrosis and attenuates bile canalicular abnormalities in Opisthorchis viverrini-infected hamsters.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2016 Jan; Vol. 12 (1), pp. 21-32. Date of Electronic Publication: 2015 Nov 02. - Publication Year :
- 2016
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Abstract
- This study investigated the effects of nanoencapsulated curcumin (NEC) and praziquantel (PZQ) treatment on the resolution of periductal fibrosis (PDF) and bile canalicular (BC) abnormalities in Opisthorchis viverrini infected hamsters. Chronic O. viverrini infection (OV) was initially treated with either PZQ (OP) and subsequently treated with NEC (OP+NEC), curcumin (OP+Cur) or unloaded carriers (OP+carrier) daily for one month. OP+NEC treatment reduced the PDF by suppression of fibrotic markers (hydroxyproline content, α-SMA, CTGF, fibronectin, collagen I and III), cytokines (TGF-β and TNF-α) and TIMP-1, 2, 3 expression and upregulation of MMP-7, 13 genes. Higher activity of NEC in reducing fibrosis compared to curcumin was also demonstrated in in vitro studies. Moreover, OP+NEC also prevented BC abnormalities and upregulated several genes involved in bile acid metabolism. These results demonstrate that NEC and PZQ treatment reduces PDF and attenuates BC defect in experimental opisthorchiasis. From the Clinical Editor: Infection by Opisthorchis viverrini leads to liver fibrosis and affects population in SE Asia. Currently, praziquantel (PZQ) is the drug of choice but this drug has significant side effects. In this study, the authors combined curcumin (NEC) and praziquantel in a nanocarrier to test the anti-oxidative effect of curcumin in an animal model. The encouraging results may pave a way for better treatment in the future.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Anthelmintics administration & dosage
Anthelmintics chemistry
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Anti-Inflammatory Agents, Non-Steroidal chemistry
Bile Canaliculi abnormalities
Cricetinae
Curcumin chemistry
Diffusion
Drug Combinations
Fibrosis pathology
Fibrosis prevention & control
Nanocapsules administration & dosage
Nanocapsules ultrastructure
Opisthorchiasis pathology
Praziquantel chemistry
Treatment Outcome
Bile Canaliculi drug effects
Bile Canaliculi pathology
Curcumin administration & dosage
Nanocapsules chemistry
Opisthorchiasis drug therapy
Praziquantel administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26542278
- Full Text :
- https://doi.org/10.1016/j.nano.2015.10.005