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Chemical materials and their regulation of the movement of molecules.
- Source :
-
Quarterly reviews of biophysics [Q Rev Biophys] 2015 Nov; Vol. 48 (4), pp. 424-8. - Publication Year :
- 2015
-
Abstract
- Materials chemistry has been fundamental to the enormous field that encompasses the delivery of molecules both to desired sites and/or at desired rates and durations. The field encompasses the delivery of molecules including fertilizers, pesticides, herbicides, food ingredients, fragrances and biopharmaceuticals. A personal perspective is provided on our early work in this field that has enabled the controlled release of ionic substances and macromolecules. Also discussed are new paradigms in creating biomaterials for human use, the non-invasive delivery of molecules through the skin and lungs, the development of intelligent delivery systems and extensions to nanomedicine. With the advent of potentially newer biopharmaceutics such as siRNA, mRNA and gene editing approaches and their use being limited by delivery, future research in this field may be more critical than ever before.
- Subjects :
- Animals
Antibodies chemistry
Biocompatible Materials chemistry
Biological Assay
Biophysical Phenomena
Delayed-Action Preparations
Drug Delivery Systems history
Gene Transfer Techniques
History, 20th Century
Humans
Ions
Macromolecular Substances
Materials Testing
Models, Theoretical
Nanomedicine trends
Polymers chemistry
RNA, Messenger metabolism
RNA, Small Interfering metabolism
Chemistry methods
Subjects
Details
- Language :
- English
- ISSN :
- 1469-8994
- Volume :
- 48
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Quarterly reviews of biophysics
- Publication Type :
- Academic Journal
- Accession number :
- 26537401
- Full Text :
- https://doi.org/10.1017/S0033583515000165