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Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7.
- Source :
-
Diagnostic pathology [Diagn Pathol] 2015 Nov 04; Vol. 10, pp. 201. Date of Electronic Publication: 2015 Nov 04. - Publication Year :
- 2015
-
Abstract
- Background: We have recently reported the presence of the Human polyomavirus 7 (HPyV7) in human thymic epithelial tumors as assessed by diverse molecular techniques. Here we report on the co-expression of p16, retinoblastoma protein (pRb) and phosphorylated retinoblastoma protein (phospho-Rb) in human thymic epithelial tumors in relation to HPyV7.<br />Methods: PRB, phospho-RB and p16 expression was assessed by immuno-histochemistry in 37 thymomas and 2 thymic carcinomas. 17 thymomas (46 %) and 1 thymic carcinoma (50 %) were recently tested positive for HPyV7. In addition, 20 follicular hyperplasias were tested.<br />Results: Expression of pRb was observed in 35 thymomas (94.6 %), in 16 thymomas (43.2 %) the expression was strong. Phospho-Rb was observed in 31 thymomas (83.8 %). 19 thymomas (51.4 %) showed immunoreactivity for p16 of which 8 thymomas revealed very strong p16 expression. No p16 expression was detected in thymic carcinomas. In addition, no significant correlation between the presence of HPyV7 and pRb-, phospho-Rb- and p16-expression could be established. No correlation between pRb, phospho-Rb, p16 and WHO staging, Masaoka-Koga staging or the presence of MG was found. All 20 follicular hyperplasias showed expression of pRb and less expression of phospho-Rb.<br />Conclusions: Although polyomaviruses have been shown to interact with cell cycle proteins no correlation between the presence of HPyV7 and the expression of pRb, phospho-Rb and p16 in human thymic epithelial tumors was observed. In as much HPyV7 contributes to human thymomagenesis remains to be established. Our data indicate pRb, phospho-Rb and p16 expression are rather unlikely to be involved in HPyV7 related thymomagenesis.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Immunohistochemistry methods
Male
Middle Aged
Neoplasms, Glandular and Epithelial diagnosis
Thymoma diagnosis
Thymoma metabolism
Thymoma pathology
Thymus Neoplasms diagnosis
Cyclin-Dependent Kinase Inhibitor p16 metabolism
Neoplasms, Glandular and Epithelial metabolism
Neoplasms, Glandular and Epithelial virology
Polyomavirus isolation & purification
Retinoblastoma Protein metabolism
Thymus Neoplasms metabolism
Thymus Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 1746-1596
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- Diagnostic pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26537237
- Full Text :
- https://doi.org/10.1186/s13000-015-0418-6