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Immunocytochemical localization of the calcium-binding proteins calbindin D28K, calretinin, and parvalbumin in bat visual cortex.
- Source :
-
Histology and histopathology [Histol Histopathol] 2016 Mar; Vol. 31 (3), pp. 317-27. Date of Electronic Publication: 2015 Nov 04. - Publication Year :
- 2016
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Abstract
- It is a common misconception that bats are blind, and various studies have suggested that bats have visual abilities. The purpose of this study was to investigate the cytoarchitecture of calbindin D28K (CB)-, calretinin (CR)-, and parvalbumin (PV)-immunoreactive (IR) neurons in the bat visual cortex using immunocytochemistry. The highest density of CB- and PV-IR neurons was located in layer IV of the visual cortex. The majority of CB- and PV-IR neurons were characterized by a stellate or round/oval shape. CR-IR neurons were predominantly located in layers II/III, and the cells were principally round/oval in shape. Two-color immunofluorescence revealed that 65.96%, 24.24%, and 77.00% of the CB-, CR-, and PV-IR neurons, respectively, contained gamma-aminobutyric acid (GABA). We observed calcium-binding protein (CBP)-IR neurons in specific layers of the bat visual cortex and in specific cell types. Many of the CBP-IR neurons were GABAergic interneurons. These data provide useful clues to aid in understanding the functional aspects of the bat visual system.
- Subjects :
- Animals
Calbindin 1 analysis
Calbindin 1 biosynthesis
Calbindin 2 analysis
Calbindin 2 biosynthesis
Chiroptera
Fluorescent Antibody Technique
Immunohistochemistry
Neurons metabolism
Parvalbumins analysis
Parvalbumins biosynthesis
Visual Cortex metabolism
Neurons cytology
Visual Cortex cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1699-5848
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Histology and histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 26536416
- Full Text :
- https://doi.org/10.14670/HH-11-680