No evidence of asymptomatic variant CJD infection in immunodeficiency patients treated with UK-sourced immunoglobulin.

Authors :: Helbert MR
Bangs C
Bishop M
Molesworth A
Ironside J
Source :: Vox sanguinis [Vox Sang] 2016 Apr; Vol. 110 (3), pp. 282-4. Date of Electronic Publication: 2015 Nov 03.
Publication Year :: 2016
Abstract: Surveillance of 75 immunodeficiency patients exposed to UK-sourced immunoglobulin, including batches derived from donors who went on to develop vCJD, has not detected any clinical cases of vCJD, or of asymptomatic infection in 15 patients with available tissue samples of sufficient quality for testing.<br /> (© 2015 International Society of Blood Transfusion.)

Subjects :: Adult
Asymptomatic Infections
Blood Donors
Genotype
Humans
Immunologic Deficiency Syndromes pathology
Polymorphism, Genetic
Prion Proteins genetics
Creutzfeldt-Jakob Syndrome transmission
Immunoglobulins, Intravenous administration & dosage
Immunologic Deficiency Syndromes drug therapy

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