Double Copies of bla(KPC-3)::Tn4401a on an IncX3 Plasmid in Klebsiella pneumoniae Successful Clone ST512 from Italy.

Authors :: Fortini D
Villa L
Feudi C
Pires J
Bonura C
Mammina C
Endimiani A
Carattoli A
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Nov 02; Vol. 60 (1), pp. 646-9. Date of Electronic Publication: 2015 Nov 02 (Print Publication: 2016).
Publication Year :: 2015
Abstract: A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid.<br /> (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)

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