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The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain.
- Source :
-
Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2016 Mar; Vol. 30 (2), pp. 115-23. Date of Electronic Publication: 2015 Nov 03. - Publication Year :
- 2016
-
Abstract
- Background: Few studies comment on the association between fibroids and symptoms among pregnant women. These studies generally are retrospective and do not to assess the influence of number of tumours or their volume on risk of symptoms.<br />Methods: Right from the Start is a prospective cohort that enrolled pregnant women from the southeastern USA between 2000 and 2012. In the first trimester, all participants had standardised ultrasounds to determine the presence or absence of fibroids. Symptoms were queried in a telephone survey. We used polytomous logistic regression to model odds of bleeding, pain, or both symptoms in relation to increasing total fibroid number and volume among white and black women.<br />Results: Among 4509 participants, the prevalence of fibroids was 11%. Among those reporting symptoms (70%), 11% reported only bleeding, 59% reported only pain, and 30% reported both symptoms. After adjusting for age, race, parity, hypertension, smoking, alcohol use, and study site, increasing number of fibroids was associated with pain [odds ratio (OR) 1.16, 95% confidence interval (CI) 1.00, 1.33] and both symptoms [OR 1.25, 95% CI 1.08, 1.45] but not with bleeding among all women. Fibroid volume was not associated with symptoms among black women, but white women with the smallest fibroid volumes were more likely to report both symptoms than those without fibroids [OR 1.79, 95% CI 1.17, 2.72].<br />Conclusions: Very large tumours are not requisite for experiencing symptoms, as small fibroids and increasing number of tumours are associated with pain and both symptoms.<br /> (© 2015 John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Black or African American ethnology
Female
Humans
Pain etiology
Pregnancy
Pregnancy Complications, Cardiovascular etiology
Pregnancy Trimester, First
Prospective Studies
United States epidemiology
Uterine Hemorrhage etiology
Uterine Neoplasms complications
White People ethnology
Young Adult
Pain ethnology
Pregnancy Complications, Cardiovascular ethnology
Pregnancy Complications, Neoplastic ethnology
Uterine Hemorrhage ethnology
Uterine Neoplasms ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3016
- Volume :
- 30
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Paediatric and perinatal epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 26525634
- Full Text :
- https://doi.org/10.1111/ppe.12256