A Domino Diels-Alder Approach toward the Tetracyclic Nicandrenone Framework.

Authors :: Mackay EG
Nörret M
Wong LS
Louis I
Lawrence AL
Willis AC
Sherburn MS
Source :: Organic letters [Org Lett] 2015 Nov 20; Vol. 17 (22), pp. 5517-9. Date of Electronic Publication: 2015 Nov 02.
Publication Year :: 2015
Abstract: The tetracarbocyclic framework of the nicandrenone natural products is formed in one step from a linear precursor via a domino intramolecular Diels-Alder/intramolecular furan Diels-Alder/aromatization sequence. The approach represents a new 0 → ABCD strategy for the preparation of aromatic steroids.