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Epigenetics and Bruxism: Possible Role of Epigenetics in the Etiology of Bruxism.
- Source :
-
The International journal of prosthodontics [Int J Prosthodont] 2015 Nov-Dec; Vol. 28 (6), pp. 594-9. - Publication Year :
- 2015
-
Abstract
- Bruxism is defined as a repetitive jaw muscle activity characterized by clenching or grinding of the teeth and/or bracing or thrusting of the mandible. There are two distinct circadian phenotypes for bruxism: sleep bruxism (SB) and awake bruxism, which are considered separate entities due to the putative difference in their etiology and phenotypic variance. The detailed etiology of bruxism so far remains unknown. Recent theories suggest the central regulation of certain pathophysiological or psychological pathways. Current proposed causes of bruxism appear to be a combination of genetic and environmental (G×E) factors, with epigenetics providing a robust framework for investigating G×E interactions, and their involvement in bruxism makes it a suitable candidate for epigenetic research. Both types of bruxism are associated with certain epigenetically determined disorders, such as Rett syndrome (RTT), Prader-Willi syndrome (PWS), and Angelman syndrome (AS), and these associations suggest a mechanistic link between epigenetic deregulation and bruxism. The present article reviews the possible role of epigenetic mechanisms in the etiology of both types of bruxism based on the epigenetic pathways involved in the pathophysiology of RTT, PWS, and AS, and on other epigenetic disruptions associated with risk factors for bruxism, including sleep disorders, altered stress response, and psychopathology.
Details
- Language :
- English
- ISSN :
- 0893-2174
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The International journal of prosthodontics
- Publication Type :
- Academic Journal
- Accession number :
- 26523718
- Full Text :
- https://doi.org/10.11607/ijp.4126