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Evaluation of antisecretory, gastroprotective and in-vitro antacid capacity of Fumaria indica in rats.
- Source :
-
Journal of environmental biology [J Environ Biol] 2015 Sep; Vol. 36 (5), pp. 1137-42. - Publication Year :
- 2015
-
Abstract
- Fumaria indica is used for its anthelmintic, antidyspeptic, cholagogue, diaphoretic, diuretic, laxative, stomachic, tonic properties and claimed to possess various properties for the ailments of blood, skin, gastrointestinal systems and central nervous system. The present study was undertaken to evaluate antisecretory, gastroprotective and in-vitro antacid capacity of ethanol extract from F. indica in rats. Evaluation of F. indica extract as antisecretory was carried out by pyloric ligation induced ulcer model. The gastroprotective effect was carried out by absolute ethanol induced ulcer model. Integrity of gastric mucosa was evaluated by estimation of GSH and gastric mucus level. The in-vitro antacid capacity was evaluated by titration method. Ethanol extract of F. indica at 200 mg kg(-1), orally showed inhibition of secretion in pyloric ligation model. GSH level (1.67 μg mg(-1) protein), gastricwall mucus (240.76 μg g(-1) wet glandular tissue) and percentage protection (77.59%) of ulcer were significantly (P < 0.05) increased in absolute ethanol induced ulcer model. The in-vitro antacid capacity of ethanol extract of F. indica was compared with the standard. Conclusively, it appears that F. indica possess antisecretory (inhibition of acid secretion), gastroprotective (potentiation of defensive factors) and in-vitro antacid activity.
- Subjects :
- Animals
Antacids chemistry
Anti-Ulcer Agents chemistry
Dose-Response Relationship, Drug
Ethanol toxicity
Female
Male
Mucus
Plant Extracts chemistry
Rats
Rats, Wistar
Stomach drug effects
Stomach pathology
Stomach Ulcer prevention & control
Antacids pharmacology
Anti-Ulcer Agents pharmacology
Fumaria chemistry
Plant Extracts pharmacology
Stomach Ulcer chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0254-8704
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of environmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 26521557