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Distinguishing benign from pathologic TH2 immunity in atopic children.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2016 Feb; Vol. 137 (2), pp. 379-87. Date of Electronic Publication: 2015 Oct 27. - Publication Year :
- 2016
-
Abstract
- Background: Although most children with asthma and rhinitis are sensitized to aeroallergens, only a minority of sensitized children are symptomatic, implying the underlying operation of efficient anti-inflammatory control mechanisms.<br />Objective: We sought to identify endogenous control mechanisms that attenuate expression of IgE-associated responsiveness to aeroallergens in sensitized children.<br />Methods: In 3 independent population samples we analyzed relationships between aeroallergen-specific IgE and corresponding allergen-specific IgG (sIgG) and associated immunophenotypes in atopic children and susceptibility to asthma and rhinitis, focusing on responses to house dust mite and grass.<br />Results: Among mite-sensitized children across all populations and at different ages, house dust mite-specific IgG/IgE ratios (but not IgG4/IgE ratios) were significantly lower in children with asthma compared with ratios in those without asthma and lowest among the most severely symptomatic. This finding was mirrored by relationships between rhinitis and antibody responses to grass. Depending on age/allergen specificity, 20% to 40% of children with allergen-specific IgE (sIgE) of 0.35 kU/L or greater had negative skin test responses, and these children also expressed the high sIgG/sIgE immunophenotype. sIgG1 from these children inhibited allergen-induced IgE-dependent basophil activation in a dose-dependent fashion. Profiling of aeroallergen-specific CD4(+) TH memory responses revealed positive associations between sIgG/sIgE ratios and IL-10-dependent gene signatures and significantly higher IL-10/TH2 cytokine (protein) ratios among nonsymptomatic children.<br />Conclusion: In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor. We posit that its production during allergen-induced memory responses contributes significantly to attenuation of inflammation through promoting IgG1-mediated damping of the FcεRI-dependent acute-phase reaction. sIgG1/sIgE balance might represent a readily accessible therapeutic target for asthma/rhinitis control.<br /> (Copyright © 2015 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Allergens immunology
Animals
Antibody Specificity immunology
Asthma diagnosis
Asthma genetics
Asthma immunology
Asthma metabolism
Basophils immunology
Basophils metabolism
Child
Child, Preschool
Cytokines metabolism
Female
Gene Expression Profiling
Humans
Hypersensitivity, Immediate diagnosis
Hypersensitivity, Immediate genetics
Hypersensitivity, Immediate metabolism
Immunoglobulin E blood
Immunoglobulin E immunology
Immunoglobulin G blood
Immunoglobulin G immunology
Immunologic Memory
Male
Phenotype
Poaceae adverse effects
Pyroglyphidae immunology
Severity of Illness Index
Th2 Cells metabolism
Hypersensitivity, Immediate immunology
Immunity
Th2 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 137
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26518094
- Full Text :
- https://doi.org/10.1016/j.jaci.2015.08.044