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Hepatitis B virus (HBV) receptors: Deficiency in tumor results in scant HBV infection and overexpression in peritumor leads to higher recurrence risk.
- Source :
-
Oncotarget [Oncotarget] 2015 Dec 15; Vol. 6 (40), pp. 42952-62. - Publication Year :
- 2015
-
Abstract
- Hepatitis B virus (HBV) infection is a risk factor for hepatocarcinogenesis and recurrence. Here, we sought to characterize intratumoral and peritumoral expression of HBsAg and its specific receptors in HBsAg-positive hepatocellular carcinoma (HCC) patients and further examined their correlation with the recurrence-free survival (RFS). HCC tissue and adjacent normal tissue specimens were acquired from HBsAg-positive patients. The presence of HBsAg and receptors, as well as hepatic progenitor cells (HPCs) were detected by tissue microassay and immunohistochemistry. Necroinflammatory activity was evaluated by HE staining. The mean IOD of HBsAg and HBV DNA in the intratumoral tissues was markedly lower than that in the peritumoral tissues (P < 0.001). Pearson correlation analysis further showed a significant correlation between the expression of HBsAg and NTCP (r = 0.461, P < 0.001) or ASGPR (r = 0.506, P < 0.001) in peritumoral tissues. And the peritumoral HBsAg and receptors presented a positive association with necroinflammatory activity (P < 0.05). Inflammation induced by HBV infection presented a positive association with HPCs activation (P < 0.05). Additionally, due to lack of HBV receptors, HPCs was not preferentially infected with HBV, but activated HPCs had a significant correlation with HBsAg expression in peritumoral tissues, and the peritumoral HPCs activation was associated with RFS of HCC patients, therefore, the overexpression of HBsAg and receptors in peritumor were also with higher recurrence risk (P < 0.05). In conclusion, lack of HBV receptors resulted in scant HBV infection in tumor cells, and overexpression of HBsAg and receptors in peritumor was strongly associated with higher recurrence risk in HCC patients.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Asialoglycoprotein Receptor analysis
Asialoglycoprotein Receptor biosynthesis
Carcinoma, Hepatocellular mortality
Child
DNA, Viral analysis
Disease-Free Survival
Female
Hepatitis B Surface Antigens analysis
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Inflammation pathology
Inflammation virology
Kaplan-Meier Estimate
Liver Neoplasms mortality
Male
Middle Aged
Neoplasm Recurrence, Local pathology
Organic Anion Transporters, Sodium-Dependent analysis
Organic Anion Transporters, Sodium-Dependent biosynthesis
Symporters analysis
Symporters biosynthesis
Tissue Array Analysis
Young Adult
Carcinoma, Hepatocellular pathology
Carcinoma, Hepatocellular virology
Hepatitis B complications
Liver Neoplasms pathology
Liver Neoplasms virology
Neoplasm Recurrence, Local virology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-2553
- Volume :
- 6
- Issue :
- 40
- Database :
- MEDLINE
- Journal :
- Oncotarget
- Publication Type :
- Academic Journal
- Accession number :
- 26515593
- Full Text :
- https://doi.org/10.18632/oncotarget.5518