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Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.
- Source :
-
Respiratory research [Respir Res] 2015 Oct 29; Vol. 16, pp. 133. Date of Electronic Publication: 2015 Oct 29. - Publication Year :
- 2015
-
Abstract
- The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.
- Subjects :
- Aged
Case-Control Studies
Female
Humans
Immunohistochemistry
Lung physiopathology
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive diagnosis
Pulmonary Disease, Chronic Obstructive etiology
Pulmonary Disease, Chronic Obstructive physiopathology
Severity of Illness Index
Smoking adverse effects
Up-Regulation
CCAAT-Enhancer-Binding Protein-beta analysis
Lung chemistry
Pulmonary Disease, Chronic Obstructive metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1465-993X
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- Respiratory research
- Publication Type :
- Academic Journal
- Accession number :
- 26511475
- Full Text :
- https://doi.org/10.1186/s12931-015-0297-0