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Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review.

Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review.

Authors :
Mendling W
Weissenbacher ER
Gerber S
Prasauskas V
Grob P
Source :
Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2016 Mar; Vol. 293 (3), pp. 469-84. Date of Electronic Publication: 2015 Oct 27.
Publication Year :
2016

Abstract

Background: Vaginal infections are responsible for a large proportion of gynaecological outpatient visits. Those are bacterial vaginosis (BV), vulvovaginal candidosis (VVC), aerobic vaginitis (AV) associated with aerobic bacteria, and mixed infections. Usual treatments show similar acceptable short-term efficacy, but frequent recurrences and increasing microbial resistance are unsolved issues. Furthermore, vaginal infections are associated with a variety of serious adverse outcomes in pregnancy and generally have a major impact on quality of life. Identifying the correct therapy can be challenging for the clinician, particularly in mixed infections.<br />Findings: Dequalinium chloride (DQC) is an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity. Systemic absorption after vaginal application of DQC is very low and systemic effects negligible. Vaginal DQC (Fluomizin vaginal tablets) has been shown to have equal clinical efficacy as clindamycin in the treatment of BV. Its broad antimicrobial activity makes it appropriate for the treatment of mixed vaginal infections and in case of uncertain diagnosis. Moreover, resistance of pathogens is unlikely due to its multiple mode of action, and vaginal DQC provides also a reduced risk for post-treatment vaginal infections.<br />Conclusions: Vaginal DQC (10 mg) as 6-day therapy offers a safe and effective option for empiric therapy of different vaginal infections in daily practice. This review summarizes the available and relevant pharmacological and clinical data for the therapy of vaginal infections with vaginal DQC and provides the rationale for its use in daily gynaecologic practice.

Details

Language :
English
ISSN :
1432-0711
Volume :
293
Issue :
3
Database :
MEDLINE
Journal :
Archives of gynecology and obstetrics
Publication Type :
Academic Journal
Accession number :
26506926
Full Text :
https://doi.org/10.1007/s00404-015-3914-8