Back to Search
Start Over
Recurrent inactivating RASA2 mutations in melanoma.
- Source :
-
Nature genetics [Nat Genet] 2015 Dec; Vol. 47 (12), pp. 1408-10. Date of Electronic Publication: 2015 Oct 26. - Publication Year :
- 2015
-
Abstract
- Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.
- Subjects :
- High-Throughput Nucleotide Sequencing methods
Humans
Melanoma mortality
Melanoma pathology
Prognosis
Skin Neoplasms mortality
Skin Neoplasms pathology
Survival Rate
Biomarkers, Tumor genetics
Exome genetics
Melanoma genetics
Mutation genetics
Skin Neoplasms genetics
ras GTPase-Activating Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 47
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 26502337
- Full Text :
- https://doi.org/10.1038/ng.3427